{
  "source_file": "clinvar_hg38_all.vcf.gz",
  "source_path": "/net/public_html/users/voy/clinvar_hg38_all.vcf.gz",
  "source_url": "https://users.abdenlab.org/voy/clinvar_hg38_all.vcf.gz",
  "source_sha256": "b6ad57a5551c0f8095b6d1887d07bb69e3e6e3ef2ab4a70eb2010f45c6300712",
  "source_records": 4471367,
  "chr19_records": 255991,
  "elements": 2823,
  "overlapping_variants": 14780,
  "elements_with_overlap": 973,
  "element_variant_pairs": 14783,
  "max_variants_per_element": 297,
  "clinical_significance_counts": {
    "Uncertain significance": 147844,
    "Likely benign": 59949,
    "-": 13192,
    "Benign": 10401,
    "Affects": 20,
    "Benign/Likely benign": 3278,
    "Conflicting classifications of pathogenicity": 7676,
    "Pathogenic": 6320,
    "Likely pathogenic": 4964,
    "Pathogenic/Likely pathogenic": 1722,
    "not provided": 454,
    "risk factor": 17,
    "no classification for the single variant": 37,
    "Conflicting classifications of pathogenicity; risk factor": 1,
    "Uncertain risk allele": 1,
    "Likely risk allele": 2,
    "Uncertain significance/Uncertain risk allele": 2,
    "Conflicting classifications of pathogenicity; association": 1,
    "protective; risk factor": 1,
    "other": 1,
    "Conflicting classifications of pathogenicity; other": 1,
    "association": 13,
    "VUS-mid": 2,
    "Benign; risk factor": 1,
    "VUS-high": 4,
    "Pathogenic; Affects": 2,
    "no classifications from unflagged records": 5,
    "drug response": 33,
    "Likely pathogenic, low penetrance": 1,
    "Uncertain significance/VUS-high": 1,
    "Pathogenic; drug response": 20,
    "Likely pathogenic; drug response": 10,
    "Uncertain significance; drug response": 3,
    "Pathogenic/Likely pathogenic; drug response": 2,
    "Conflicting classifications of pathogenicity; drug response": 1,
    "Conflicting classifications of pathogenicity; other; risk factor": 1,
    "confers sensitivity": 5,
    "confers sensitivity; other": 1,
    "Uncertain significance; risk factor": 1,
    "Uncertain significance; association": 1
  },
  "filtering": "Chromosome only; no clinical-significance or phenotype filter",
  "overlap_convention": "0-based half-open REF span [POS-1, POS-1+len(REF)); includes indel anchors",
  "protected_files_unchanged": true,
  "protected_sha256": {
    "chr19.matrix.csv": "084a1dbb3d125d3dbec5a9f72c850a00112530771068f459cfb78b5a0c833c99",
    "chr19.ccre.matrix.csv": "622e7694b9324ddd8d65cdf51224d9570b67534ece2de8428b626198faaec3f6",
    "chr19.ccre_metadata.csv": "a9edd59837f7fd31816ee39fb5c1286503fbdeca9ab6af2a89f36071d540a6cb",
    "chr19.json": "57c30865fd7b0d45f77f0025c39d3db1dc2c791e7b2be684d25982c438774571"
  },
  "browser_rendering_verified": false,
  "bedtools_overlap_crosscheck": true,
  "row_alignment_verified": true,
  "config_references_valid": true,
  "counts_and_groups_verified": true
}