EXPERIMENT_TITLE: Hi-C-seq of SiHa
STUDY_DESCRIPTOR_STUDY_ABSTRACT: In order to characterize different scales of genome organization during cervical cancer development, we have used NHEK normal human epidermal keratinocyte and SiHa tumorigenic cervical cancer cells and performed genome-wide Hi-C, ChIP-seq as well as RNA-seq to identify structural variations, specifically TADs. We interpretated a correlation among chromatin structure, epigenetic landscape, gene expression, and HPV-LINC00393 integrated loci in SiHa cells. The results will help us to get a better insight into HPV-LINC00393 integration in cervical carcinogenesis.
SAMPLE_TITLE: SiHa_HiC
SAMPLE_SAMPLE_ATTRIBUTES_SAMPLE_ATTRIBUTE: [{"TAG": "isolate", "VALUE": "Japanese women"}, {"TAG": "age", "VALUE": "55"}, {"TAG": "biomaterial_provider", "VALUE": "ATCC"}, {"TAG": "sex", "VALUE": "female"}, {"TAG": "tissue", "VALUE": "cervical cancer"}, {"TAG": "cell_line", "VALUE": "SiHa"}, {"TAG": "BioSampleModel", "VALUE": "Human"}]
Pool_Member_@attributes_sample_title: SiHa_HiC
RUN_SET_RUN_Pool_Member_@attributes_sample_title: SiHa_HiC
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