EXPERIMENT_TITLE: Hi-C for ovarian cancer patient sample C31408
STUDY_DESCRIPTOR_STUDY_ABSTRACT: Structural variants, such as translocations, inversions, duplications, and deletions, have long been recognized as mutations that can contribute to the initiation and progression of cancer. This can occur through a variety of mechanisms, including changes in gene dosage and the generation of fusion genes. In recent years, it is becoming increasingly clear that these events also can alter how genomes are organized in 3D space in the nucleus and contribute to changes in enhancer-promoter regulation. However, it remains poorly understand how often 3D genome structural changes occur in cancers, what genes are affected by these events, and in which tumor types. This study is part of ongoing work to better characterize 3D genome structural changes across a variety of tumor types to better... (for more see dbGaP study page.)
SAMPLE_TITLE: Tumor DNA sample from Ovary of a human female participant in the dbGaP study "Hi-C Profiling of Solid Tumor Samples"
SAMPLE_SAMPLE_ATTRIBUTES_SAMPLE_ATTRIBUTE: [{"TAG": "gap_accession", "VALUE": "phs003227"}, {"TAG": "submitter handle", "VALUE": "NCI_3D_SolidTumorGenomes"}, {"TAG": "biospecimen repository", "VALUE": "NCI_3D_SolidTumorGenomes"}, {"TAG": "study name", "VALUE": "Hi-C Profiling of Solid Tumor Samples"}, {"TAG": "study design", "VALUE": "Case Set"}, {"TAG": "biospecimen repository sample id", "VALUE": "C31408_HiC"}, {"TAG": "submitted sample id", "VALUE": "C31408_HiC"}, {"TAG": "submitted subject id", "VALUE": "C31408"}, {"TAG": "gap_sample_id", "VALUE": "5347516"}, {"TAG": "gap_subject_id", "VALUE": "4422980"}, {"TAG": "sex", "VALUE": "female"}, {"TAG": "body site", "VALUE": "Ovary"}, {"TAG": "histological type", "VALUE": "Serous Carcinoma"}, {"TAG": "analyte type", "VALUE": "DNA"}, {"TAG": "is tumor", "VALUE": "Yes"}, {"TAG": "gap_consent_code", "VALUE": "1"}, {"TAG": "gap_consent_short_name", "VALUE": "HMB-MDS"}]
Pool_Member_@attributes_sample_title: Tumor DNA sample from Ovary of a human female participant in the dbGaP study "Hi-C Profiling of Solid Tumor Samples"
RUN_SET_RUN_Pool_Member_@attributes_sample_title: Tumor DNA sample from Ovary of a human female participant in the dbGaP study "Hi-C Profiling of Solid Tumor Samples"