EXPERIMENT_TITLE: GSM8323378: Daro; Homo sapiens; Hi-C
EXPERIMENT_DESIGN_LIBRARY_DESCRIPTOR_LIBRARY_CONSTRUCTION_PROTOC: DNA were extracted using Arima Genomics HiC kit Hi-C-library preparation
STUDY_DESCRIPTOR_STUDY_ABSTRACT: This study investigates the role of noncoding RNAs in resistance to the anti-androgen drug daro-lutamide in prostate cancer. RNA sequencing identified LOC730101 as a significantly elevated lncRNA in darolutamide-resistant cells. Silencing LOC730101 reduced cell proliferation, indicating its role in drug resistance. Overall design: To investigate the lncRNA function in DaroR resistant cells
SAMPLE_TITLE: Daro
SAMPLE_SAMPLE_ATTRIBUTES_SAMPLE_ATTRIBUTE: [{"TAG": "source_name", "VALUE": "Prostate cancer"}, {"TAG": "tissue", "VALUE": "Prostate cancer"}, {"TAG": "cell line", "VALUE": "LNCaP"}, {"TAG": "cell type", "VALUE": "hormone sensitive prostate cancer"}, {"TAG": "genotype", "VALUE": "Drug treated"}, {"TAG": "treatment", "VALUE": "10uM_Darolutamide"}, {"TAG": "geo_loc_name", "VALUE": "missing"}, {"TAG": "collection_date", "VALUE": "missing"}]
Pool_Member_@attributes_sample_title: Daro
RUN_SET_RUN_Pool_Member_@attributes_sample_title: Daro
RUN_SET_RUN_SRAFiles_SRAFile: [{"Alternatives": null, "@attributes": {"cluster": "public", "filename": "Daro_1.fq.gz", "size": "57094031999", "date": "2024-06-12 11:25:19", "md5": "8b82b4b129ac9a2b4bb3f34df4aeac92", "version": "1", "semantic_name": "fastq", "supertype": "Original", "sratoolkit": "0"}}, {"Alternatives": null, "@attributes": {"cluster": "public", "filename": "Daro_2.fq.gz", "size": "60008369138", "date": "2024-06-12 11:23:08", "md5": "52ac29b4cbeaa8affbed6033afe1b7d0", "version": "1", "semantic_name": "fastq", "supertype": "Original", "sratoolkit": "0"}}, {"Alternatives": null, "@attributes": {"cluster": "public", "filename": "SRR29369901", "url": "https://sra-pub-run-odp.s3.amazonaws.com/sra/SRR29369901/SRR29369901", "size": "74838695844", "date": "2024-06-12 11:30:46", "md5": "6c654509b7520fbfc9dc522409daca59", "version": "1", "semantic_name": "SRA Normalized", "supertype": "Primary ETL", "sratoolkit": "1"}}, {"Alternatives": [null, null, null], "@attributes": {"cluster": "public", "filename": "SRR29369901.lite", "url": "https://sra-downloadb.be-md.ncbi.nlm.nih.gov/sos6/sra-pub-zq-40/SRR029/29369/SRR29369901/SRR29369901.lite.1", "size": "60938442676", "date": "2024-06-12 12:56:36", "md5": "f9c8b2878b246beffc2e5d87c9786694", "version": "1", "semantic_name": "SRA Lite", "supertype": "Primary ETL", "sratoolkit": "1"}}]