EXPERIMENT_TITLE: Hi-C of hiNSCs
STUDY_DESCRIPTOR_STUDY_ABSTRACT: How 3D genome organization regulates cell fate transition remains poorly understood at present. By multiomics analyses integrating the Hi-C data, PTF1A and CTCF DNA-binding profiles, H3K27ac modification, and gene expression, we demonstrate that 3D genome reorganization as a driving force instrumental for cellular transcription program changes and cell fate transitions, and highlight an essential role for PTF1A in orchestrating multiscale 3D genome remodeling during cell reprogramming.
SAMPLE_SAMPLE_ATTRIBUTES_SAMPLE_ATTRIBUTE: [{"TAG": "isolate", "VALUE": "PTF1A induced NSC derived human fibroblasts"}, {"TAG": "age", "VALUE": "4"}, {"TAG": "biomaterial_provider", "VALUE": "Zhongshan Ophthalmic Center"}, {"TAG": "collection_date", "VALUE": "2021"}, {"TAG": "geo_loc_name", "VALUE": "China"}, {"TAG": "sex", "VALUE": "male"}, {"TAG": "tissue", "VALUE": "foreskin"}, {"TAG": "ID", "VALUE": "6"}, {"TAG": "BioSampleModel", "VALUE": "Human"}]
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