EXPERIMENT_TITLE: GSM4115516: Hi-C_HCT116OxR; Homo sapiens; Hi-C
EXPERIMENT_DESIGN_LIBRARY_DESCRIPTOR_LIBRARY_CONSTRUCTION_PROTOC: The cross-linked cells were lysed in lysis buffer,fragmentation of the genome using restriction enzymes Hi-C libraries were prepared for sequencing using standard Illumina protocols
STUDY_DESCRIPTOR_STUDY_ABSTRACT: Numerous studies have highlighted the critical role of genetic and epigenetic modifications in the regulation of oxaliplatin resistance, but whether changes involving chromatin structure have not been fully investigated. We have integrated a variety of techniques to explore a comprehensive overview of chromatin changes in oxaliplatin-resistant processes. Overall design: HCT116 cells and oxaliplatin-resistant HCT116 cells, HCT116OxR
SAMPLE_TITLE: Hi-C_HCT116
SAMPLE_SAMPLE_ATTRIBUTES_SAMPLE_ATTRIBUTE: [{"TAG": "source_name", "VALUE": "HCT116 cells"}, {"TAG": "tissue", "VALUE": "Colorectal cancer"}, {"TAG": "cell type", "VALUE": "HCT116 cells"}, {"TAG": "genotype", "VALUE": "Oxaliplatin-unresistant"}]
Pool_Member_@attributes_sample_title: Hi-C_HCT116
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