EXPERIMENT_TITLE: Hi-C of human female 1 CD4+ T-cells: Sample HF1_CD4_HiC_repA_L2
STUDY_DESCRIPTOR_STUDY_ABSTRACT: Changes in gene expression are a critical force driving the evolution of form and function. As a result, the mechanisms by which gene expression evolves have become a subject of intense interest. A number of investigators have measured evolutionary changes in gene expression at the chromatin, mRNA, and protein levels, leading to new insights about how species evolve. However, studies of different stages in gene expression have not always been in agreement. For example, the extremely rapid rates of evolutionary changes that have been widely observed at enhancers appear to conflict with the slower rates observed in mRNA abundance. We recently completed a major comparative study in primates showing that this disparity between enhancer and mRNA evolution, in part, reflects extensive... (for more see dbGaP study page.)
SAMPLE_TITLE: Non-tumor DNA sample from Blood of a human female participant in the dbGaP study "Evolution of Chromatin Architecture and Transcriptional Regulation in Mammals"
SAMPLE_SAMPLE_ATTRIBUTES_SAMPLE_ATTRIBUTE: [{"TAG": "gap_accession", "VALUE": "phs002146"}, {"TAG": "submitter handle", "VALUE": "NHGRI_Chromatin_TranscriptionalRegulation"}, {"TAG": "biospecimen repository", "VALUE": "NHGRI_Chromatin_TranscriptionalRegulation"}, {"TAG": "study name", "VALUE": "Evolution of Chromatin Architecture and Transcriptional Regulation in Mammals"}, {"TAG": "study design", "VALUE": "Collection"}, {"TAG": "biospecimen repository sample id", "VALUE": "HF1_CD4_HiC_repA_L2"}, {"TAG": "submitted sample id", "VALUE": "HF1_CD4_HiC_repA_L2"}, {"TAG": "submitted subject id", "VALUE": "HF1"}, {"TAG": "gap_sample_id", "VALUE": "4447994"}, {"TAG": "gap_subject_id", "VALUE": "3548892"}, {"TAG": "sex", "VALUE": "female"}, {"TAG": "body site", "VALUE": "Blood"}, {"TAG": "histological type", "VALUE": "CD4+ T-cells"}, {"TAG": "analyte type", "VALUE": "DNA"}, {"TAG": "is tumor", "VALUE": "No"}, {"TAG": "gap_consent_code", "VALUE": "1"}, {"TAG": "gap_consent_short_name", "VALUE": "GRU"}]
Pool_Member_@attributes_sample_title: Non-tumor DNA sample from Blood of a human female participant in the dbGaP study "Evolution of Chromatin Architecture and Transcriptional Regulation in Mammals"
RUN_SET_RUN_Pool_Member_@attributes_sample_title: Non-tumor DNA sample from Blood of a human female participant in the dbGaP study "Evolution of Chromatin Architecture and Transcriptional Regulation in Mammals"