EXPERIMENT_TITLE: aged rep1
STUDY_DESCRIPTOR_STUDY_ABSTRACT: We used Hi-C technology to reveal the landscape of three-dimensional chromatin architecture for the brains of AD patients. By comparing to that of age-matched and younger individuals without dementia, we reported that AD patients were more affected during ageing and AD genesis. Differential interaction analysis indicated four class of long-distance interaction shift during AD genesis and ageing. Among them, feedback class was wide-spread. We reported a more detailed long-distance interaction pattern between active regulatory regions, especially within gene body of the same genes, and observed that most of known AD risk genes were under long-distance promoter-enhancer interactions.
SAMPLE_TITLE: aged rep1
SAMPLE_SAMPLE_ATTRIBUTES_SAMPLE_ATTRIBUTE: [{"TAG": "isolate", "VALUE": "aged normal P1"}, {"TAG": "age", "VALUE": "90"}, {"TAG": "biomaterial_provider", "VALUE": "China Brain Bank of Zhejiang University School of Medicine"}, {"TAG": "sex", "VALUE": "female"}, {"TAG": "tissue", "VALUE": "brain"}, {"TAG": "disease", "VALUE": "aged normal"}, {"TAG": "braak", "VALUE": "0"}, {"TAG": "sequencing depth", "VALUE": "medium"}, {"TAG": "PMI(Min)", "VALUE": "300"}, {"TAG": "CSF PH", "VALUE": "7"}, {"TAG": "Neuron Loss", "VALUE": "weak"}, {"TAG": "BioSampleModel", "VALUE": "Human"}]
Pool_Member_@attributes_sample_title: aged rep1
RUN_SET_RUN_Pool_Member_@attributes_sample_title: aged rep1
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