EXPERIMENT_TITLE: young rep3
STUDY_DESCRIPTOR_STUDY_ABSTRACT: We used Hi-C technology to reveal the landscape of three-dimensional chromatin architecture for the brains of AD patients. By comparing to that of age-matched and younger individuals without dementia, we reported that AD patients were more affected during ageing and AD genesis. Differential interaction analysis indicated four class of long-distance interaction shift during AD genesis and ageing. Among them, feedback class was wide-spread. We reported a more detailed long-distance interaction pattern between active regulatory regions, especially within gene body of the same genes, and observed that most of known AD risk genes were under long-distance promoter-enhancer interactions.
SAMPLE_TITLE: young rep3
SAMPLE_SAMPLE_ATTRIBUTES_SAMPLE_ATTRIBUTE: [{"TAG": "isolate", "VALUE": "young normal P6"}, {"TAG": "age", "VALUE": "29"}, {"TAG": "biomaterial_provider", "VALUE": "Chinese Brain Bank center in Wuhan"}, {"TAG": "sex", "VALUE": "female"}, {"TAG": "tissue", "VALUE": "brain"}, {"TAG": "disease", "VALUE": "young normal"}, {"TAG": "braak", "VALUE": "0"}, {"TAG": "sequencing depth", "VALUE": "high"}, {"TAG": "PMI(Min)", "VALUE": "310"}, {"TAG": "CSF PH", "VALUE": "7"}, {"TAG": "Neuron Loss", "VALUE": "no"}, {"TAG": "BioSampleModel", "VALUE": "Human"}]
Pool_Member_@attributes_sample_title: young rep3
RUN_SET_RUN_Pool_Member_@attributes_sample_title: young rep3
RUN_SET_RUN_SRAFiles_SRAFile: [{"Alternatives": null, "@attributes": {"cluster": "public", "filename": "SRR12596533", "url": "https://sra-pub-run-odp.s3.amazonaws.com/sra/SRR12596533/SRR12596533", "size": "310832084089", "date": "2020-10-05 15:20:28", "md5": "630d59f020e8029218c44c34486f9252", "version": "1", "semantic_name": "SRA Normalized", "supertype": "Primary ETL", "sratoolkit": "1"}}, {"Alternatives": [null, null, null], "@attributes": {"cluster": "public", "filename": "SRR12596533.lite", "url": "https://sra-downloadb.be-md.ncbi.nlm.nih.gov/sos3/sra-pub-zq-22/SRR012/12596/SRR12596533/SRR12596533.lite.1", "size": "229205168521", "date": "2022-07-21 06:34:13", "md5": "263a99e7423360337811b321c27869ae", "version": "1", "semantic_name": "SRA Lite", "supertype": "Primary ETL", "sratoolkit": "1"}}]