EXPERIMENT_TITLE: GSM8323379: DaroR; Homo sapiens; Hi-C
EXPERIMENT_DESIGN_LIBRARY_DESCRIPTOR_LIBRARY_CONSTRUCTION_PROTOC: DNA were extracted using Arima Genomics HiC kit Hi-C-library preparation
STUDY_DESCRIPTOR_STUDY_ABSTRACT: This study investigates the role of noncoding RNAs in resistance to the anti-androgen drug daro-lutamide in prostate cancer. RNA sequencing identified LOC730101 as a significantly elevated lncRNA in darolutamide-resistant cells. Silencing LOC730101 reduced cell proliferation, indicating its role in drug resistance. Overall design: To investigate the lncRNA function in DaroR resistant cells
SAMPLE_TITLE: DaroR
SAMPLE_SAMPLE_ATTRIBUTES_SAMPLE_ATTRIBUTE: [{"TAG": "source_name", "VALUE": "Prostate cancer"}, {"TAG": "tissue", "VALUE": "Prostate cancer"}, {"TAG": "cell line", "VALUE": "LNCaP_DaroR"}, {"TAG": "cell type", "VALUE": "hormone non-sensitive prostate cancer"}, {"TAG": "genotype", "VALUE": "Drug treated"}, {"TAG": "treatment", "VALUE": "10uM_Darolutamide"}, {"TAG": "geo_loc_name", "VALUE": "missing"}, {"TAG": "collection_date", "VALUE": "missing"}]
Pool_Member_@attributes_sample_title: DaroR
RUN_SET_RUN_Pool_Member_@attributes_sample_title: DaroR
RUN_SET_RUN_SRAFiles_SRAFile: [{"Alternatives": null, "@attributes": {"cluster": "public", "filename": "DaroR_1.fq.gz", "size": "50559809545", "date": "2024-06-12 11:12:53", "md5": "271ecbcd5e1c0abb11f8585bdad80b18", "version": "1", "semantic_name": "fastq", "supertype": "Original", "sratoolkit": "0"}}, {"Alternatives": null, "@attributes": {"cluster": "public", "filename": "DaroR_2.fq.gz", "size": "53324530657", "date": "2024-06-12 11:10:43", "md5": "05aace8c678a0caa41af7a3f04f11fd9", "version": "1", "semantic_name": "fastq", "supertype": "Original", "sratoolkit": "0"}}, {"Alternatives": null, "@attributes": {"cluster": "public", "filename": "SRR29369900", "url": "https://sra-pub-run-odp.s3.amazonaws.com/sra/SRR29369900/SRR29369900", "size": "66572055931", "date": "2024-06-12 11:24:59", "md5": "e6fd7bd308edbe4ab07df5b5680ac88e", "version": "1", "semantic_name": "SRA Normalized", "supertype": "Primary ETL", "sratoolkit": "1"}}, {"Alternatives": [null, null, null], "@attributes": {"cluster": "public", "filename": "SRR29369900.lite", "url": "https://sra-downloadb.be-md.ncbi.nlm.nih.gov/sos6/sra-pub-zq-40/SRR029/29369/SRR29369900/SRR29369900.lite.1", "size": "53497844171", "date": "2024-06-12 12:34:17", "md5": "f1f4279a244b97d8f28161b966e01157", "version": "1", "semantic_name": "SRA Lite", "supertype": "Primary ETL", "sratoolkit": "1"}}]