EXPERIMENT_TITLE: young rep2
STUDY_DESCRIPTOR_STUDY_ABSTRACT: We used Hi-C technology to reveal the landscape of three-dimensional chromatin architecture for the brains of AD patients. By comparing to that of age-matched and younger individuals without dementia, we reported that AD patients were more affected during ageing and AD genesis. Differential interaction analysis indicated four class of long-distance interaction shift during AD genesis and ageing. Among them, feedback class was wide-spread. We reported a more detailed long-distance interaction pattern between active regulatory regions, especially within gene body of the same genes, and observed that most of known AD risk genes were under long-distance promoter-enhancer interactions.
SAMPLE_TITLE: young rep2
SAMPLE_SAMPLE_ATTRIBUTES_SAMPLE_ATTRIBUTE: [{"TAG": "isolate", "VALUE": "young normal P5"}, {"TAG": "age", "VALUE": "30"}, {"TAG": "biomaterial_provider", "VALUE": "Chinese Brain Bank center in Wuhan"}, {"TAG": "sex", "VALUE": "female"}, {"TAG": "tissue", "VALUE": "brain"}, {"TAG": "disease", "VALUE": "young normal"}, {"TAG": "braak", "VALUE": "0"}, {"TAG": "sequencing depth", "VALUE": "high"}, {"TAG": "PMI(Min)", "VALUE": "260"}, {"TAG": "CSF PH", "VALUE": "7.3"}, {"TAG": "Neuron Loss", "VALUE": "no"}, {"TAG": "BioSampleModel", "VALUE": "Human"}]
Pool_Member_@attributes_sample_title: young rep2
RUN_SET_RUN_Pool_Member_@attributes_sample_title: young rep2
RUN_SET_RUN_SRAFiles_SRAFile: [{"Alternatives": [null, null, null], "@attributes": {"cluster": "public", "filename": "SRR12596534.lite", "url": "https://sra-downloadb.be-md.ncbi.nlm.nih.gov/sos3/sra-pub-zq-22/SRR012/12596/SRR12596534/SRR12596534.lite.1", "size": "210051462252", "date": "2022-07-21 16:53:28", "md5": "80be28a3769d762d0839297c8eec3ddd", "version": "1", "semantic_name": "SRA Lite", "supertype": "Primary ETL", "sratoolkit": "1"}}, {"Alternatives": null, "@attributes": {"cluster": "public", "filename": "SRR12596534", "url": "https://sra-pub-run-odp.s3.amazonaws.com/sra/SRR12596534/SRR12596534", "size": "292048854476", "date": "2020-10-04 21:15:57", "md5": "e7221751d587083a90a3bd0cad4527f7", "version": "1", "semantic_name": "SRA Normalized", "supertype": "Primary ETL", "sratoolkit": "1"}}]