{
  "schema_version": "1.0.0",
  "provider": "SIGNOR",
  "relation_kind": "curated causal protein relation; not physical-binding or HPRD parity",
  "source": {
    "url": "https://signor.uniroma2.it/API/getHumanData.php",
    "sha256": "5be15571d1282ff791fa2b9c05bae9dd7cc4cedbba7d41ee1aa1236d752f6ae6",
    "retrieved_at": "2026-10-03T18:44:07.623524+00:00",
    "release": "date/hash-pinned live export; no immutable provider release ID",
    "license": "CC-BY-4.0",
    "license_url": "https://signor.uniroma2.it/about/",
    "citation": "Lo Surdo et al. SIGNOR4.0: the 2025 update with focus on phosphorylation data. DOI:10.1093/nar/gkaf1237"
  },
  "slice": {
    "TYPEA": "protein",
    "TYPEB": "protein",
    "DIRECT": "t",
    "TAX_ID": "9606",
    "DATABASEA": "UNIPROT",
    "DATABASEB": "UNIPROT"
  },
  "coverage": {
    "raw_records": 40790,
    "selected_records": 18069,
    "excluded_records": 22721,
    "violated_slice_fields": {
      "TYPEA": 7983,
      "TYPEB": 8337,
      "DIRECT": 5688,
      "TAX_ID": 9730,
      "DATABASEA": 7983,
      "DATABASEB": 8337
    },
    "exclusion_count_semantics": "field counts overlap; excluded_records is the union"
  },
  "columns": [
    "ENTITYA",
    "TYPEA",
    "IDA",
    "DATABASEA",
    "ENTITYB",
    "TYPEB",
    "IDB",
    "DATABASEB",
    "EFFECT",
    "MECHANISM",
    "RESIDUE",
    "SEQUENCE",
    "TAX_ID",
    "CELL_DATA",
    "TISSUE_DATA",
    "MODULATOR_COMPLEX",
    "TARGET_COMPLEX",
    "MODIFICATIONA",
    "MODASEQ",
    "MODIFICATIONB",
    "MODBSEQ",
    "PMID",
    "DIRECT",
    "NOTES",
    "ANNOTATOR",
    "SENTENCE",
    "SIGNOR_ID",
    "SCORE"
  ],
  "artifact": {
    "path": "interaction_edges.parquet",
    "sha256": "dc0ebc4e755931f2c1b2bd27814ebb5bbe1d8741b67403a68773102ea36fc39b",
    "records": 18069
  },
  "mapping": "Exact source ENTITY symbols to verified assay gene_symbols only; no alias, orthology or site-specific inference"
}