OpportunityTitle: The Effects of Modulating Chronic Low Grade Inflammation on Geriatric Conditions: Secondary Data and/or Biospecimen Analyses and Ancillary Studies in Ongoing or Completed Clinical Trials (R01)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.  Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Description: The purpose of this Funding Opportunity Announcement (FOA) is to invite applications to perform ancillary studies and secondary analyses of data and/or biospecimens from ongoing or completed studies of the effects of inflammation and/or anti-inflammatory agents on geriatric conditions, such as functional decline, mobility disability, fatigue, falls, cognitive decline/dementia, and chronic pain. Data that can inform designs of possible future interventional studies on modulating the effects of chronic inflammation in such conditions are of particular interest. Analyses of both beneficial and harmful effects of modulating chronic inflammation in older individuals are of interest. Other types of studies of interest to NIA include mechanistic studies to explore the pathophysiologic processes by which chronic, low-grade inflammation may accelerate functional decline or other geriatric conditions, and how these pathways may be disrupted by interventions. The secondary analyses and ancillary studies supported by this (FOA) may be based on data and/or biospecimens from either ongoing or completed clinical trials.
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GrantorContactText: NIH OER Webmaster&lt;br/&gt;FBOWebmaster@OD.NIH.GOV&lt;br/&gt;