OpportunityTitle: Limited Competition: Renewal of the Aging Intervention Testing Program (U01)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:   Only the current awardees of Intervention Testing Program (ITP) funded under RFA-AG-09-013 are eligible to apply under this Limited Competition FOA.    Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.  Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.    Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Description: The purpose of the Aging Interventions Testing Program (ITP) is to test, under standardized conditions in multiple sites, potential intervention strategies which may decelerate the rate of aging in mammals. The rate of aging is to be measured by lifespan extension and/or improvements in health at later ages due to the intervention. The ITP has used life span as its primary outcome for an intervention, with limited studies on end-of-life pathologies and selected tests of health across the lifespan (health span). This FOA calls for renewal and expansion of the ITP with the following goals: 1. Continue to test compounds for effects on lifespan; 2. Increase analysis of pharmacodynamics and pharmacokinetics of compounds proposed for lifespan studies, including studies of optimal effective dose; 3. Increase histology and pathophysiology analyses at time-of-death; 4. Increase focused studies of health span on selected compounds; 5. Establish a data coordinating center.
GrantorContactEmailDescription: If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster
GrantorContactText: NIH OER Webmaster &lt;br/&gt;FBOWebmaster@OD.NIH.GOV &lt;br/&gt;