OpportunityTitle: Limited Competition for Data Coordinating Center (DCC) for NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) (U24)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Description: The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) was established in July, 2002 for the purpose of identifying genes predisposing to IBD. Since its establishment, the IBDGC, in collaboration with the International IBD Genetics Consortium, has identified about 200 such susceptibility loci. However, most of these loci include multiple genes, and for the great majority of the loci, specific casual genes and alleles have not yet been identified. The mechanisms by which the most of the causative genes influence IBD pathophysiology also remain unknown. The purpose of this FOA is to renew the IBDGC to identify risk-conferring and protective variants of causal genes for IBD, and to elucidate the mechanisms by which these variants influence the pathophysiology of IBD. The DCC will coordinate collaboration among the Genetic Research Centers (GRCs, described in the companion FOA RFA-DK-16-029), enrollment of subjects into the study, submission of blood and other biological samples to centralized repositories, processing of blood samples for extraction of DNA and isolation of cells and serum, submission of clinical, genetic, and molecular data to central databases, and analyses of data, and manage the operations of the Steering Committee and other operational committees. The DCC will also coordinate the development of pilot projects for rapid follow-up of emerging findings by members of the IBDGC and external collaborators. In addition, the DCC will coordinate the collaboration of the IBDGC with the International IBDGC, and with other external investigators conducting ancillary studies. The PD/PI of the DCC shall serve as a voting member of the Steering Committee of the IBDGC, and be bound by all of the operational decisions of this Committee.
GrantorContactEmailDescription: If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster
GrantorContactText: NIH OER Webmaster&lt;br/&gt;FBOWebmaster@OD.NIH.GOV&lt;br/&gt;