OpportunityTitle: Fine Mapping and Function of Genes for Type 1 Diabetes (DP3)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Non-domestic (non-U.S.) Entities (Foreign Organizations); Tribally Controlled Colleges and Universities (TCCUs) .
Description: -Purpose. This FOA issued by the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, solicits Research Project Grant (DP3) applications from institutions/organizations for research on projects to carry out fine mapping studies as well as to investigate the function of the genes involved in type 1 diabetes. To date, genome-wide association studies (GWAS) of type 1 diabetes have yielded promising results. However, follow-up studies are needed to eliminate false positives, extend the findings to diverse populations (diverse in terms of ethnicity or environmental exposures) and narrow the association interval. The purpose of this funding opportunity is to provide support for replication and fine-mapping studies of genetic regions putatively associated with type 1 diabetes. In addition, studies of the function of the genes identified and the mechanisms by which they may alter risk are needed. This initiative will also solicit proposals on the application of new technologies to genetics of type 1 diabetes and the study of the role of these genes in the etiopathogenesis of type 1 DM. The identification of these genes and function will help define etiological pathways and leads for new therapeutic targets. -Mechanism of Support. This FOA will utilize the DP3 grant mechanism. -Funds Available and Anticipated Number of Awards. The total funding for this five year program this year is $20 million for the five year period. It is anticipated that 4-10 awards will be made.
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GrantorContactText: NIH OER Webmaster&lt;br/&gt;FBOWebmaster@OD.NIH.GOV&lt;br/&gt;