OpportunityTitle: Assay Development for High Throughput Molecular Screening (R21)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Description: Purpose. This FOA will facilitate the discovery of new molecular probes for investigating biological function by funding the development and adaptation of biological assays for use in automated High-Throughput Screening (HTS) projects. These HTS-ready assays can then be screened by the Molecular Libraries Production Centers Network (MLPCN) to identify biologically active compounds in a large library of small molecule chemical structures. This Program and the MLPCN are both components of the NIH Molecular Libraries and Imaging Roadmap Initiative (http://nihroadmap.nih.gov/molecularlibraries/index.asp). Mechanism of Support. This FOA will use a modified NIH Exploratory/ Developmental (R21) award mechanism. Funds Available and Anticipated Number of Awards. Approximately $6 million will be available for this FOA in 2011. This amount will be distributed in response to two due dates. NIH anticipates making approximately 30 awards in total in 2011. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.
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