OpportunityTitle: Optimizing Recovery and Preservation of Endogenous Insulin Secretion in Individuals with Prediabetes or Recent Onset of Type 2 Diabetes (U01)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Description: This FOA, issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), solicits applications for clinical studies to investigate strategies that promote the recovery and maintenance of endogenous insulin secretion among individuals who have prediabetes or are early in the course of type 2 diabetes. Specifically, the aim of this initiative is 1) To assess whether short, intensive interventions can substantially improve the pattern and magnitude of the endogenous insulin response, the extent to which recovery is possible and to identify the factors associated with recovery and retention of endogenous insulin secretion, and 2) To determine the duration of the effect and whether this will facilitate achieving better glucose control. In addition, studies may seek to identify biomarkers that will simplify assessment of beta cell function and improve prediction of whether a given individual will respond positively to the intervention. Although each investigator will propose and conduct a unique protocol, collaboration will be required among awardees to establish common definitions, measures and procedures to promote comparisons of data across protocols.
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GrantorContactText: NIH OER Webmaster&lt;br/&gt;FBOWebmaster@OD.NIH.GOV&lt;br/&gt;