OpportunityTitle: Coordinating Center for Systems Biology Approach to the Mechanisms of Tuberculosis (TB) Latency and Reactivation (R01)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Description: Purpose. The National Heart, Lung, and Blood Institute solicits applications under this funding opportunity announcement (FOA) to participate as Data Coordinating Center for the NHLBI Systems Biology Approach to the Mechanisms of Tuberculosis (TB) Latency and Reactivation program. The NHLBI Systems Biology Approach to TB Program will include multiple TB Systems Biology Centers and one Data Coordinating Center. This program is designed to investigate the mechanisms of latency and the reactivation of tuberculosis in the host using integrated systems biology approaches. Systems biology is defined in many ways. For the purposes of this FOA we are using a definition found on the MIT CSBi website a research program that links biologists, computer scientists, and engineers in a multi disciplinary approach to the systematic analysis of complex biological phenomena. The studies should include multiscale computational modeling and focus on host lung responses to Mycobacterium tuberculosis (Mtb) and host-microbial interactions that drive latency and reactivation in humans. To build the theoretical models human and animal data should be utilized. The studies should integrate the data obtained from omic approaches with biological/immunological data. The models should be such that they can be tested in humans or non-human primates. The use of human samples and or data is required. However, the additional use of animal models/data in building and testing the models is encouraged to enable a better understanding of latency and reactivation in humans. This FOA solicits applications for the Data Coordinating Center and runs in parallel with a separate FOA that solicits applications for up to four TB Systems Biology Centers (see RFA-HL-10-015)
GrantorContactEmailDescription: If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster
GrantorContactText: NIH OER Webmaster&lt;br/&gt;FBOWebmaster@OD.NIH.GOV&lt;br/&gt;