OpportunityTitle: Clinical Trials in Organ Transplantation (CTOT) (U01)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.  Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Description: This FOA invites applications from groups of two (2) or more institutions to participate in a clinical studies program to improve the long-term outcome of transplant recipients (thoracic organ, abdominal organ and vascular composite tissue). The Clinical Trials in Organ Transplantation (CTOT) program will support a cooperative, multi-institutional consortium for the conduct of interventional trials (Phase 1, 2, or 3) or observational clinical studies in organ or vascularized composite allotransplantation (VCA). Each clinical study must include associated mechanistic studies that focus on immune-mediated pathologic processes in allotransplantation or on mechanisms of immune activation and quiescence. The goals of this research will be to target immune-mediated causes of morbidity and mortality in transplant recipients and evaluate interventions to address them.
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GrantorContactText: NIH OER Webmaster&lt;br/&gt;FBOWebmaster@OD.NIH.GOV&lt;br/&gt;