OpportunityTitle: Centers for Advanced Diagnostics and Experimental Therapeutics in Lung Diseases Stage I(CADET I) (P50)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Description: Purpose. The purpose of this FOA issued by the NHLBI, National Institutes of Health, is to invite applications for clinical research centers for Centers for Advanced Diagnostics and Experimental Therapeutics in Lung Diseases Stage I (CADET I).The overall goal of the CADET program (Stages I and II) is to accelerate the development of novel agents for the diagnosis and treatment of lung diseases and sleep disordered breathing through the use of rational strategies based on fundamental pathobiologic processes. CADET I provides the opportunity to explore potential target(s) for validation to determine which are amenable for development of mechanism-based modalities for direct clinical application in the prevention, diagnosis, and treatment of pulmonary diseases and sleep disordered breathing. Companion FOAs for Clinical Research Centers (CRCs) and a Data Coordinating Center (DCC) for CADET Stage II (CADET II) will be released at a later date.Both the CRCs and DCC announcements will be open competitions.Centers that have been awarded in CADET I may apply for Clinical Research Centers in CADET II. Mechanism of Support. This FOA will utilize the P50 award mechanism. Funds Available and Anticipated Number of Awards. Contingent upon the availability of funding, the total amount to be awarded for CADET I will be a maximum of $30 million for the total program.It is anticipated that up to 30 awards, under this FOA, will be awarded for CADET I. Budget and Project Period.The total project period for an application submitted in response to this FOA is 2 years.Budgets for direct costs of up to $300,000 per year (exclusive of indirect costs associated with consortia) and a project duration of up to 2 years may be requested for a maximum of $600,000 direct costs over a 2-year project period.Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the numbers, quality, duration, and costs of the applications received. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.
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