OpportunityTitle: Kidney Precision Medicine Project  Recruitment Sites (UG3/UH3)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Description: This Funding Opportunity Announcement (FOA) requests applications for the Kidney Precision Medicine Project (KPMP) Recruitment Sites (RS) to recruit participants with either acute kidney injury (AKI) or chronic kidney disease (CKD) into longitudinal cohort studies. The RS will collaborate with the KPMP Tissue Interrogation Sites and Central Hub to obtain and evaluate kidney biopsies from participants, create a kidney tissue atlas, define disease subgroups, and identify critical cells, pathways and targets for novel therapies. Applicants should propose to study either AKI or CKD, outline initial cohorts of interest, provide inclusion/exclusion criteria, and estimate recruitment targets given the FOA budget and KPMP objectives. Applicants should have documented experience with patient recruitment and safely obtaining kidney biopsies for clinical and/or research purposes. The initial UG3 exploratory phase will be used to demonstrate that the site can recruit and follow a sufficient number of well-characterized participants with either AKI or CKD, and safely obtain high-quality research kidney biopsies while conforming to the highest ethical, research and clinical standards. UG3 projects that have met their milestones will be administratively considered by the NIDDK and prioritized for transition to the UH3 implementation phase. UH3 awards will support continued recruitment into larger cohort studies. Applicants to this FOA must address both the UG3 and UH3 phases. This FOA is intended to support only human studies and applications that include animal or model systems are not responsive.
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GrantorContactText: NIH OER Webmaster&lt;br/&gt;FBOWebmaster@OD.NIH.GOV&lt;br/&gt;