OpportunityTitle: Natural History of Disorders Identifiable by Newborn Screening (R01)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:   Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Description: Purpose. This FOA issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, solicits Research Project Grant (R01) applications from institutions/ organizations that propose to develop a comprehensive understanding of the natural history of disorders that are currently identified by NBS or could potentially benefit from early identification by newborn screening. By defining the sequence and timing of the onset of symptoms and complications of a disorder, a valuable resource will be developed for the field.In addition, for some disorders, specific genotype-phenotype correlations may allow prediction of the clinical course, and for other disorders, identification of modifying genetic, epigenetic, or environmental factors will enhance an understanding of the clinical outcomes for an individual with such a condition. Comprehensive data on natural history will facilitate the field&apos;s ability to: 1) accurately diagnose the disorder; 2) understand the genetic and clinical heterogeneity and phenotypic expression of the disorder; 3) identify underlying mechanisms related to basic defects; 4) potentially prevent, manage, and treat symptoms and complications of the disorder; and 5) provide children and their families with needed support and predictive information about the disorder. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism Funds Available and Anticipated Number of Awards. The NICHD intends to commit a total of approximately $2,000,000 to this FOA in FY11 to award up to 2 applications. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Budget and Project Period. An applicant may request a budget of up to five years and total costs of up to $1,000,000 in each of the project years to support multi-state consortia of screening programs that are able provide natural history information for one or more disorders.
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