OpportunityTitle: Clinical Trials in Organ Transplantation in Children and Adults (CTOT-CA) (U01 Clinical Trial Optional)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.  Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.  Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Description: The purpose of this FOA is to solicit applications to participate in a clinical studies program to improve the long-term outcome of adult and pediatric transplant recipients (thoracic organ, abdominal organ, vascular composite tissue, and cellular replacement). The Clinical Trials in Organ Transplantation in Children and Adults (CTOT-CA) program will support cooperative, multi-institutional consortia for the conduct of interventional trials (Phase 1, 2, or 3) or observational clinical studies in organ, vascularized composite tissue, or cellular replacement allotransplantation. Each applicant institution must represent a consortium of 2 or more clinical sites. Each clinical study must include associated mechanistic studies that focus on immune-mediated processes that are relevant to the proposed clinical study. The goals of this research will be to further our understanding of and ultimately reduce immune- and infection-mediated morbidity and mortality of allotransplantation.
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GrantorContactText: NIH OER Webmaster&lt;br/&gt;FBOWebmaster@OD.NIH.GOV