OpportunityTitle: Collaborative Research on the Transition From Acute to Chronic Pain: New Models and Measures in Clinical and Preclinical Pain Research (R01)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Description: Purpose. The overall goal of this FOA is to stimulate preclinical and clinical research that will accelerate our understanding of the biological and behavioral determinants driving the transition from acute pain to chronic pain disorders. An understanding of the mechanisms and risk factors that determine who will transition to a chronic pain state is necessary in order to intervene in this transition and to design new, effective treatments to resolve acute pain before it becomes chronic. The objectives of this FOA are to: 1) assemble research teams with expertise in basic and clinical pain research and related expertise outside the pain field that will provide novel, collaborative, multidisciplinary approaches to answer crucial questions about the transition from acute to chronic pain; 2) discover biological and behavioral mechanisms that drive the transition from an acute pain state to a chronic dysfunctional pain condition; 3) develop new clinical and preclinical models and measures of pain that will be essential to identify and characterize these mechanisms. Studies that involve considerable risk but with the potential for breakthroughs in the field are strongly encouraged. Mechanism of Support. This FOA will utilize the R01 grant mechanism. Funds Available and Anticipated Number of Awards. The NIDCR intends to commit $5 million total costs in FY 2011 to support meritorious projects solicited through this FOA. We anticipate that 7-10 awards will be made, depending upon the number and quality of applications received and the availability of funds. Budget and Project Period. Because the nature and scope of the proposed research will vary among applications, it is anticipated that the size and duration of each award will also vary.However, the total project period for an application submitted in response to this FOA may not exceed five years.Although R01 applications are not limited in dollars, budgets should be appropriate for the proposed work.
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