OpportunityTitle: Development of Sample Sparing Assays for Monitoring Immune Responses (U24)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Description: The purpose of this funding opportunity announcement (FOA) is to accelerate the development and validation of sample sparing assays that can be applied for studying the human immune system in health and disease.Development of sample sparing assays will lead to maximum use of the sampled material by significant reduction of sample volumes/amounts required or by simultaneous multi-parameter assessments of immune function.By expanding the spectrum of parameters that can be measured on small samples derived from human subjects, assays developed in response to this announcement will be valuable for advancing our fundamental understanding of the immune system and equally important for immune monitoring in healthy as well as disease conditions such as allergy, asthma, autoimmunity, acquired and primary immunodeficiency, transplantation, and infection.New sample sparing assays will have a major impact on clinical studies aimed to understand immune functions in young children with infectious diseases and/or immune mediated disorders; for example, food allergy, diabetes or primary immunodeficiency where sample availability is most limited.
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GrantorContactText: NIH OER Webmaster&lt;br/&gt;FBOWebmaster@OD.NIH.GOV&lt;br/&gt;