OpportunityTitle: Audacious Goals Initiative High Priority Research Area:  Intersection of Aging and Biological Mechanisms of Eye Disease (R01)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.  Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Description: The purpose of this Funding Opportunity Announcement (FOA) for the National Eye Institute (NEI) is to encourage submission of new, innovative projects directed to exploring this area through: 1) understanding how the biology of aging contributes to disease; 2) evaluating how the failure of homeostatic processes causes or allows the transition from aging to early disease; 3) defining the biological staging of disease to understand pathophysiology, identify biomarkers, and explore therapy; and 4) distinguishing normal ocular changes associated with aging from pathophysiologic changes. Advanced age is a risk factor for many of the leading causes of vision loss, including age-related macular degeneration, cataract, glaucoma, diabetic retinopathy, dry eye syndrome, and presbyopia. Better knowledge of the biological mechanisms of disease will lead to new strategies to prevent or delay progress of these age-related blinding conditions. An application may propose design-directed, developmental, discovery-driven, or hypothesis-driven research. It is appropriate to propose small, multidisciplinary teams applying an integrative approach to solve these problems.
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GrantorContactText: NIH OER Webmaster&lt;br/&gt;FBOWebmaster@OD.NIH.GOV&lt;br/&gt;