OpportunityTitle: Production Of Human Proteins To Be Used For Generating Affinity Reagents (U01)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Description: Purpose. This FOA is the first component of a pilot program organized under the NIH Common Fund Protein Capture Initiative to examine the feasibility and value of generating a community resource of high quality, renewable affinity reagents for all human proteins. This specific FOA topic is focused on the production of proteins or peptides for the purpose of generating monoclonal antibodies that can be used in immunoprecipitation studies, and potentially for other affinity reagents, as well as broader uses by the scientific community and others. Thus, the FOA solicits projects that will provide the targeted proteins, peptides or other immunogens to other components of the pilot program (including a component that will generate monoclonal antibodies, to be solicited in FY2011), as well as to the wider community in the form of a renewable resource, e.g., clones or transfected cell lines.This FOA will prioritize human transcription factors as an initial set of targets. Mechanism of Support. This FOA will utilize the U01 Research Project Cooperative Agreement activity code. Funds Available and Anticipated Number of Awards..We expect to fund a single three year award in FY2010. Total funds available for the program are $1M, for each of three years.. Budget and Project Period.Applications should propose no more than $600,000 in direct costs per year over a period of no more than three years.
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