OpportunityTitle: Oral Immune System Plasticity in Chronic HIV Infection Under Treatment and Oral Co-Infections (R01)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Description: This Funding Opportunity Announcement (FOA) solicits research projects that study the mechanisms of oral immune system plasticity relevant to chronic HIV infection and oral coinfections.In this context, we encourage studies on reversal of immune activation, residual inflammation, immune reconstitution inflammatory syndrome (IRIS), and microbial and by-product translocation.These conditions occur in persons chronically infected with HIV who are treated with combination antiretroviral therapy (cART) and who also experience oral opportunistic infections.The ultimate goals of this FOA are: 1) to gain knowledge regarding the pathogenesis and persistence of these oral conditions; and 2) to guide the development of novel oral immune modulatory therapies that will aid in re-building the oral immune system to reverse these diseases, mitigate their progression, prevent their occurrence, and eliminate persistence of residual HIV and other oral pathogens in reservoirs.
GrantorContactEmailDescription: If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster
GrantorContactText: NIH OER Webmaster&lt;br/&gt;FBOWebmaster@OD.NIH.GOV&lt;br/&gt;