OpportunityTitle: Integrating Supersaturation-precipitation Mechanisms in Mechanistic Oral Absorption Models for Predicting In- vivo Performance of Associated Formulations  (U01)
AdditionalInformationOnEligibility: Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.  Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.  Foreign components, as defined in the HHS Grants Policy Statement, are allowed.
Description: The objectives of this project are to: 1) integrate in vivo supersaturation-precipitation mechanisms into mechanism-based oral absorption models for poorly water-soluble drugs formulated into supersaturable systems, and 2) to establish a mechanism-based in vitro-in vivo correlation (IVIVC) for these drug products.
GrantorContactEmailDescription: eric.bozoian@fda.hhs.gov
GrantorContactText: Eric Bozoian &lt;br/&gt;Grants Management Specialist &lt;br/&gt;Phone 2404027623