OpportunityTitle: Secondary Analyses of CALERIE Data Set and Stored Biospecimens to Address Research Questions Related to Effects of Caloric Restriction in Humans and Adherence to Caloric Restriction Interventions (R01)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Description: The National Institute on Aging (NIA) invites applications for short-term (up to two years) projects involving secondary analysis of CALERIE (Comprehensive Assessment of Long-term Effects of Restricting Intake of Energy) data set and / or stored biospecimens. The goal of these studies is to test the hypotheses about effects of sustained caloric restriction (CR) on protective and risk factors for aging processes and diseases associated with aging, psychological effects and safety of CR, and other specific candidate hypotheses based on pre-clinical animal and cell culture data on mechanisms affecting aging.Applicants are strongly encouraged to apply tools capturing an integrated, global picture of the effects of CR on multiple systems simultaneously. These approaches may include screening in domains such as the proteome, metabolome, transcriptome, and others.
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GrantorContactText: NIH OER Webmaster&lt;br/&gt;FBOWebmaster@OD.NIH.GOV&lt;br/&gt;