OpportunityTitle: Network for Personalization of Diagnostic Tests for Alzheimers Disease (AD) and Alzheimers Disease-Related Dementias (ADRD) in Older Adults with Multiple Chronic Conditions (MCCs) (U24 Clinical Trial Optional)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.  Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.  Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Description: This Funding Opportunity Announcement (FOA) invites applications to establish a network that will conduct transdisciplinary aging diagnostic biomarker and/or imaging research projects focused on Alzheimers Disease and Alzheimers Disease-Related Dementias (AD/ADRD) in persons living with Multiple Chronic Conditions (MCCs). The aim of the research is to better align diagnostic testing with the needs and priorities of an aging population. The national consortium will: 1) assemble existing data and acquire real-world data to ensure that the research sample is large and diverse, with adequate representation of older adults living with well-characterized MCCs, and incorporate pre-specified subgroup analyses; 2) analyze data for performance and accuracy of biomarkers, to include blood, cerebrospinal fluid (CSF), and imaging, in older patients living with MCCs; and 3) conduct pilot studies involving specific AD/ADRD imaging and/or biomarkers in persons living with MCCs.
GrantorContactEmailDescription: See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.
GrantorContactText: NIH OER Webmaster&lt;br/&gt;OERWebmaster03@od.nih.gov