OpportunityTitle: Systems Approach to Immunity and Inflammation (U19)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply. Foreign (non-U.S.) components of U.S. Organizations are allowed.
Description: The primary objective of the program is to use a systems biology approach to develop a comprehensive understanding of innate or adaptive immune responses to infection with and/or vaccination against one or more pathogenic microbes, with a focus on NIAID Emerging/Re-emerging Pathogens of concern to human health. The initiative will support quantitative analyses that will identify and measure dynamic networks regulating immune responses. The basis of the research program will be genome wide screens of mutant mice for identification of key regulatory immune response genes. The studies will be complemented by detailed genomics, proteomics, computational biology and bioinformatics approaches that focus on transcriptional regulation and signaling mechanisms. Investigators will analyze a subset of the newly discovered murine immune regulatory genes in human correlation studies.
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