OpportunityTitle: Pathophysiology of Bisphosphonates-associated Osteonecrosis of the Jaw (R03)
AdditionalInformationOnEligibility: Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith-based or community-based organizations can apply. Applicants may submit more than one application, provided each application is scientifically distinct.     Projects must focus on studying oral bone homeostasis, healing response or repair capacity in the presence or absence of bisphosphonates rather than on the broad effects of bisphosphonates on bone quality. Projects that examine the effects of bisphosphonates on skeletal biology will not be considered unless the experimental design includes analysis of oral bones. Projects may study the effects of bisphosphonates on other physiological processes such as angiogenesis but only within the context that perturbation of these processes may compromise oral bone homeostasis and healing.  Projects that examine the pharmacology of bisphosphonates will be considered non-responsive unless the projects propose to test whether genetic variations alter the pharmacokinetics or pharmacodynamics of bisphosphonates. Epidemiological studies are non-responsive.
Description: -The National Institute of Dental and Craniofacial Research (NIDCR) and the National Cancer Institute (NCI) invite Small Research Grant (R03) applications for research projects focusing on basic and translational studies of osteonecrosis of the jaw (ONJ), an oral complication associated with bisphosphonate use. Projects should aim to identify and characterize the pathophysiological mechanisms that lead to impaired bone healing and the development of ONJ. -This FOA will use the NIH Small Research Grant (R03) award mechanism and runs in parallel with two FOAs of identical scientific scope, PA-06-500 that solicits applications under the NIH Individual Research Project Grant (R01) mechanism, and PA-06-501 that solicits applications under the NIH Exploratory/Developmental Grant (R21) mechanism. -This R03 is intended to support pilot and developmental research that is likely to lead to a subsequent Individual Research Project Grant (R01) application from scientists who are in the early stages of establishing an independent research career. The R03 is not renewable.
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GrantorContactText: NIH OER Webmaster &lt;br/&gt;FBOWebmaster@OD.NIH.GOV &lt;br/&gt;
CloseDateExplanation: Multiple Receipt Dates - See Link to Full Announcement for details.