OpportunityTitle: Next Generation PrEP II (R01)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Foreign (non-U.S.) components of U.S. Organizations are allowed.
Description: Develop the basic and preclinical framework needed for development of second and subsequent generations of PrEP agents Create a rational pipeline for the discovery of New Molecular Entities (NMEs) and the identification of existing antiretrovirals (including those that are approved for HIV treatment, and those that are not approved but may have clinical data) that can be used for the next generation of PrEP agents Develop preclinical algorithms with clear go/no go criteria for identifying and prioritizing PrEP candidates for advancement to clinical evaluation Generate PK/PD models to assess protective effects at mucosal sites of HIV transmission Conduct proof-of-concept safety and efficacy studies in animal models
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GrantorContactText: NIH OER Webmaster&lt;br/&gt;FBOWebmaster@OD.NIH.GOV&lt;br/&gt;