OpportunityTitle: Develop, Implement, and Evaluate Evidence-based, Innovative Approaches to Prevent, Find, and Cure Tuberculosis in High-Burden Settings
AdditionalInformationOnEligibility: N/A
Description: The End TB Strategy envisions a world free of tuberculosis (TB)&#8212;zero deaths, disease and suffering due to TB by 2035. This requires reducing the global TB incidence from &gt;1250 cases per million people to &lt;100 cases per million people within the next two decades.Each year, an estimated 10 million people develop TB disease, and an estimated 1.6 million TB people die from TB &#8211; the leading cause of death from any infectious disease. In 2017, 90% of all estimated new TB cases were adults (15 years of age or older), and 9% were persons living with HIV (PLHIV) with 72% living in Africa. Despite being preventable and treatable, large gaps in detection and treatment of TB cases remain; of the estimated 10 million new TB cases in 2017, only 6.4 million TB cases were officially reported.Drug-resistant TB is on the raise, posing significant programmatic challenges. Worldwide, an estimated 580,000 multi-drug-resistant (MDR) TB cases emerge annually. Unfortunately, there are substantial gaps in MDR TB detection and treatment. Approximately 1 of 5 persons needing MDR TB treatment actually receive it, and among those who do receive treatment, less than half (48%) who start treatment finish successfully. These rates are driven by treatment failure, loss to follow-up, and premature death.Globally, it is estimated that 1.7 billion people (about one fourth of the world&#8217;s population) are infected with TB and form the next generation of future TB cases. Expanding testing and treatment of TB infection is critical to achieving our elimination goals. However, in high-burden countries, the implementation of tuberculosis preventive treatment (TPT) remains a low priority.The purpose of this NOFO is to develop, implement, and evaluate evidence-based, innovative approaches in collaboration with CDC to:prevent TB infection, disrupt TB transmission, and halt progression of TB disease in high-burden settings;find TB infection and TB disease in all populations, including those most vulnerable (i.e., children, displaced persons, healthcare workers, economically disadvantaged, PLHIV, persons with other co-morbid conditions [alcohol use disorders, diabetes mellitus, persons who use illicit substances, undernourished] and elderly)optimize treatment for TB infection, TB disease, TB/HIV, and MDR TB through new treatment and adherence modalities;improve the use of routinely collected data to monitor and evaluate TB program performance;promote operations research (i.e., local solutions for local problems) for broader application, adoption, and integration into routine TB care and treatment practice.
GrantorContactEmailDescription: Grants Policy
GrantorContactText: Lata Kumar &lt;br/&gt;lkumar@cdc.gov
CloseDateExplanation: Electronically submitted applications must be submitted no later than 5:00 p.m., ET, on the listed application due date.