OpportunityTitle: NHLBI Pediatric Cardiac Genomics Consortium (U01)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Non-domestic (non-U.S.) Entities (Foreign Organizations); Tribally Controlled Colleges and Universities (TCCUs) .
Description: -Purpose. The National Heart, Lung, and Blood Institute (NHLBI) and the Canadian Institutes of Health Research (CIHR) invite applications to participate in a new NHLBI Pediatric Cardiac Genomics Consortium, a cooperative investigative group that will conduct clinical and translational research on the genetic causes of congenital heart disease and genetic contributions to outcome in individuals with congenital heart disease.The purpose of this initiative is to support collaborative genetic and genomic research leading to a comprehensive understanding of the causes and outcomes of congenital heart disease in the human population.The Consortium will consist of up to 6 Research Centers, Cores, and a Steering Committee.Research Center applicants will propose detailed investigation of the genetics and genomics of one or more human cardiac malformations, with the goal of identifying genetic influences on outcome, as well as causative genes.Individual Research Centers will collaborate in recruitment of individuals with congenital heart disease and their families for all Research Center projects.This Consortium is part of a new NHLBI translational program in pediatric cardiovascular disease, which includes the companion NHLBI Cardiac Development Consortium (http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-09-002.html), and Administrative Coordinating Center for both Consortia (http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-09-011.html).These consortia will interact with each other and with the NHLBI Pediatric Heart Network (www.PediatricHeartNetwork.com) to encourage translation of results from basic science to clinical research, and to provide clinical input on pressing needs for basic research. -Mechanism of Support. This FOA will utilize the Research Project Cooperative Agreement (U01) mechanism of support. -Funds Available and Anticipated Number of Awards. The NHLBI intends to commit approximately $1,440,000 total costs for FY2009.The total amount to be awarded for the Pediatric Cardiac Genomics Consortium will be a maximum of $25,440,000 total costs for the six-year project period.It is anticipated that up to 6 research centers will be awarded.
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