OpportunityTitle: Host/ Gut Microbiota Response to Stressors: Informing Resiliency
Description: The Office of Naval Research (ONR) is interested in receiving proposals on research directed at understanding the effects of certain behavioral and physical stressors on the host/gut microbiota, with an emphasis on deducing the role the gut microbiota (GM) may play in mediating physiological, psychological and possibly cognitive effects of such exposures. For this topic, we do not anticipate funding any human studies. Specific objectives of this Special Notice topic are: (1) To characterize the psychological, physiological and cognitive responses of the host and GM (behavior, organism, tissue and molecular levels) following exposure to various behavioral and physical stressors, such as: abnormal circadian cycles or living conditions (such as those found on a submarine), extreme/rapid environmental shifts (e.g., altitudinal, temperature, elevated ambient noise), fatigue, anticipatory anxiety or fear. (2) To ascertain if specific gut microbial community members, metabolites or functions play a role in the observed host response to the stressor(s) listed above. Comparison with data obtained for different hosts may be informative in deducing microbial functions on host response. Specific attention will be focused on &#145;gut-brain-axis&#146; routes of signaling. (3) Support the development of novel tools for real-time analysis of microbes, the surfaces they adhere to, and microbial products in the GI tract to more closely map microbial heterogeneity and identify specific links to their function. ************************************************************************************************************************************ The FULL ANNOUNCEMENT is available on the Grants.gov website by scrolling to the top of the synopsis page and clicking on the &quot;FULL ANNOUNCEMENT&quot; box surrounded by the dotted line at the top of the page.
GrantorContactEmailDescription: See section &quot;Agency Contact&quot; for details
GrantorContactText: FOR TECHNICAL QUESTIONS: &lt;br/&gt;Dr.Linda A. Chrisey &lt;br/&gt;Program Officer &lt;br/&gt;EMAIL: Linda.Chrisey@navy.mil &lt;br/&gt; &lt;br/&gt;FOR BUSINESS QUESTIONS: &lt;br/&gt;Ganesh Krish &lt;br/&gt;Contract Specialist &lt;br/&gt;EMAIL: Ganesh.Krish@navy.mil &lt;br/&gt; &lt;br/&gt;FOR TECHNICAL ISSUES WITH GRANTS.GOV: &lt;br/&gt;Please contact Grants.Gov technical support.  Grants.gov is neither hosted nor managed by ONR.
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