OpportunityTitle: Enhancing Tumoricidal Activity of Natural Killer (NK) Cells by Dietary Components for Cancer Prevention (R21)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following: Eligible Agencies of the Federal Government Non-domestic (non-U.S.) Entities (Foreign Organizations) Regional Organizations U.S. Territory or Possession
Description: -Purpose. This funding opportunity announcement (FOA), issued by the National Cancer Institute (NCI), is designed to stimulate research efforts aimed at establishing the physiological significance of dietary components in modulating the tumoricidal cell activity of natural killer (NK) cells for cancer prevention. The focus of research projects proposed in response to this FOA should be on defining the minimum quantity and duration of exposure to specific dietary components to modulate tumoricidal cell activity of NK cells for cancer prevention and the underlying mechanism(s) accounting for this response. Proposed projects must include animal and/or human investigations to be considered responsive to this announcement. Highly purified populations of immune cells, specific tumor cells such as RMA-S that lack class I MHC expression, target cell-free system, or single-cell assays may be used to define the molecular basis for the diet-induced changes in tumoricidal activity. However, the in vitro studies are only to be used to support in vivo studies and should not constitute the primary focus of the application. Molecular targets for food components may be examined at the sites of the tumoricidal cell receptors and cancer cell specific ligands, the output of tumoricidal cytokines (e.g., IFN-g), and the release of lytic granules such as a granulysin, perforin, and serine proteases (granzymes). -Mechanism of Support. This FOA utilizes the NIH Exploratory/Developmental Grant (R21) mechanism and runs in parallel with an FOA of identical scientific scope, PA-08-131, that solicits applications under the NIH Research Project Grant (R01) mechanism.
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GrantorContactText: NIH OER Webmaster&lt;br/&gt;FBOWebmaster@OD.NIH.GOV&lt;br/&gt;