OpportunityTitle: Characterization of Pro- and Anti-Geronic Proteins and Peptides (R01)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Description: The goal of this FOA is to advance research on naturally occurring proteins (and/or peptides) known to impact one or more aging phenotypes, at physiological levels, based on whole-animal experimental evidence. These are &quot;geronic proteins&quot; isolated from circulation, which might reverse (rejuvenate) or potentially prevent development of aging phenotypes observable in an older laboratory animal, such as cardiac hypertrophy, diminished skeletal muscle repair-efficiency, reduced muscle strength, etc. (anti-geronic proteins), or which appear to promote an aging phenotype in a young adult laboratory animal, such as leading to decreased neurogenesis or cognitive function (pro-geronic proteins). (For brevity, this definition includes &quot;geronic peptides.&quot;) The pro- or anti-geronic functions of these proteins have been demonstrated to have physiological consequences at least at the level of tissue or organ function, but often have additional support for their geronic functions at the cellular and molecular levels (but, importantly, in whole-animal experiments). These anti- and pro-geronic proteins are often known to function in other biological contexts, such as development. The primary goals of this FOA are to characterize the geronic functions of these proteins. The outcome of research supported by this FOA should be an improved understanding of the range of aging phenotypes affected by geronic proteins (individually or in concert), the cellular and molecular mechanisms by which these geronic functions are exerted, and will eventually promote studies supporting the translational potential of these proteins.
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