OpportunityTitle: TaRGET II: Environmental Epigenomic Analysis in Tissue Surrogates (U01)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Description: Environmental exposure induced perturbations of epigenomic marks are correlated with disease pathogenesis.Identifying changes in epigenomic marks (e.g., DNA methylation, histone modifications, chromatin accessibility) in affected tissues/cells is not always feasible in humans. The purpose of this Funding Opportunity Announcement (FOA) is to establish a consortium that will explore the conservation of perturbations of epigenomic marks across target tissues/cells and surrogate tissues/cells using mouse models of environmentally relevant diseases. Ultimately, these analyses will provide insights into the design and interpretation of human studies where target tissues are inaccessible.
GrantorContactEmailDescription: If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster
GrantorContactText: NIH OER Webmaster&lt;br/&gt;FBOWebmaster@OD.NIH.GOV&lt;br/&gt;