OpportunityTitle: Regional Consortia for High Resolution Cryoelectron Microscopy (U24)
AdditionalInformationOnEligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Description: The purpose of this Funding Opportunity Announcement (FOA) is to provide regional access for cryoelectron microscopy (cryoEM) laboratories to state-of-the-art data collection capabilities. NIGMS will support consortia of established and early stage investigator laboratories whose research has an established specialization in and dependence on cryoEM. These laboratories will coordinate with each other to share facilities and resources for collection of high resolution data. Consortia will consist of a host institution and partner institutions. The host institution should already have a modern high-performing cryoEM installation and proven capabilities for high-resolution data collection. A consortium will support surplus capacity for cryoEM data collection (infrastructure and services) at the host institution and make it available to participating cryoEM partner laboratories at the partner institutions. These projects will support access for these partner laboratories to resources and services at host institutions. Projects will (a) contribute to the fixed costs of maintaining the host facility and extend services in proportion to the resources dedicated to the partner laboratories and (b) support expenses of access to the facility by these partners. The host institution need not already have an electron detector; this FOA can help fund acquisition of direct detection equipment. Support is limited to enabling the cryoEM partner laboratories to collect data and perform the initial stages of processing raw images, and does not include other research activities. In addition to the host institution, consortia will include a minimum of four partner institutions; award budgets will depend on the number and data collection needs of the partner laboratories. This initiative is not intended to support service centers of the traditional type in which the host laboratory performs the cryoEM analysis for non-specialist collaborators.
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