## htsjdk.samtools.metrics.StringHeader
# MarkDuplicates --INPUT DE-1.sorted.bam --OUTPUT DE-1.markdup.sorted.bam --METRICS_FILE DE-1.markdup.sorted.MarkDuplicates.metrics.txt --REMOVE_DUPLICATES false --ASSUME_SORTED true --TMP_DIR tmp --VALIDATION_STRINGENCY LENIENT --REFERENCE_SEQUENCE genome.fa --MAX_SEQUENCES_FOR_DISK_READ_ENDS_MAP 50000 --MAX_FILE_HANDLES_FOR_READ_ENDS_MAP 8000 --SORTING_COLLECTION_SIZE_RATIO 0.25 --TAG_DUPLICATE_SET_MEMBERS false --REMOVE_SEQUENCING_DUPLICATES false --TAGGING_POLICY DontTag --CLEAR_DT true --DUPLEX_UMI false --FLOW_MODE false --FLOW_QUALITY_SUM_STRATEGY false --USE_END_IN_UNPAIRED_READS false --USE_UNPAIRED_CLIPPED_END false --UNPAIRED_END_UNCERTAINTY 0 --FLOW_SKIP_FIRST_N_FLOWS 0 --FLOW_Q_IS_KNOWN_END false --FLOW_EFFECTIVE_QUALITY_THRESHOLD 15 --ADD_PG_TAG_TO_READS true --DUPLICATE_SCORING_STRATEGY SUM_OF_BASE_QUALITIES --PROGRAM_RECORD_ID MarkDuplicates --PROGRAM_GROUP_NAME MarkDuplicates --READ_NAME_REGEX <optimized capture of last three ':' separated fields as numeric values> --OPTICAL_DUPLICATE_PIXEL_DISTANCE 100 --MAX_OPTICAL_DUPLICATE_SET_SIZE 300000 --VERBOSITY INFO --QUIET false --COMPRESSION_LEVEL 5 --MAX_RECORDS_IN_RAM 500000 --CREATE_INDEX false --CREATE_MD5_FILE false --help false --version false --showHidden false --USE_JDK_DEFLATER false --USE_JDK_INFLATER false
## htsjdk.samtools.metrics.StringHeader
# Started on: Fri Jul 18 00:09:13 GMT 2025

## METRICS CLASS	picard.sam.DuplicationMetrics
LIBRARY	UNPAIRED_READS_EXAMINED	READ_PAIRS_EXAMINED	SECONDARY_OR_SUPPLEMENTARY_RDS	UNMAPPED_READS	UNPAIRED_READ_DUPLICATES	READ_PAIR_DUPLICATES	READ_PAIR_OPTICAL_DUPLICATES	PERCENT_DUPLICATION	ESTIMATED_LIBRARY_SIZE
Unknown Library	79171	87258574	22275687	0	46474	28556748	825750	0.327384	104008802

## HISTOGRAM	java.lang.Double
BIN	CoverageMult	all_sets	optical_sets	non_optical_sets
1.0	1.006103	44047908	0	44445683
2.0	1.440903	10386810	736465	10188680
3.0	1.628808	2728173	20314	2609036
4.0	1.710013	807608	3240	759726
5.0	1.745107	290784	1462	273944
6.0	1.760273	131809	856	125079
7.0	1.766827	73313	574	70370
8.0	1.76966	46238	374	44627
9.0	1.770884	31529	315	30565
10.0	1.771413	22986	206	22227
11.0	1.771641	17352	174	16686
12.0	1.77174	13372	127	13140
13.0	1.771783	10870	87	10522
14.0	1.771801	8699	77	8489
15.0	1.771809	7220	71	7035
16.0	1.771813	6057	45	5904
17.0	1.771814	5134	38	5079
18.0	1.771815	4432	40	4340
19.0	1.771815	3815	39	3692
20.0	1.771815	3300	28	3241
21.0	1.771815	2974	30	2916
22.0	1.771815	2611	23	2539
23.0	1.771815	2327	25	2335
24.0	1.771815	2120	21	2067
25.0	1.771815	1879	16	1912
26.0	1.771815	1744	14	1710
27.0	1.771815	1594	12	1518
28.0	1.771815	1416	11	1383
29.0	1.771815	1339	11	1354
30.0	1.771815	1206	9	1184
31.0	1.771815	1131	11	1084
32.0	1.771815	1023	8	1017
33.0	1.771815	949	11	958
34.0	1.771815	932	3	911
35.0	1.771815	890	4	892
36.0	1.771815	771	3	742
37.0	1.771815	787	7	805
38.0	1.771815	766	2	754
39.0	1.771815	708	5	681
40.0	1.771815	631	5	629
41.0	1.771815	599	5	611
42.0	1.771815	582	7	563
43.0	1.771815	533	1	515
44.0	1.771815	497	3	507
45.0	1.771815	527	4	492
46.0	1.771815	466	5	484
47.0	1.771815	476	0	461
48.0	1.771815	427	4	407
49.0	1.771815	371	2	392
50.0	1.771815	408	1	393
51.0	1.771815	357	2	362
52.0	1.771815	386	2	365
53.0	1.771815	332	0	333
54.0	1.771815	353	2	358
55.0	1.771815	354	1	353
56.0	1.771815	341	0	333
57.0	1.771815	294	1	286
58.0	1.771815	294	1	292
59.0	1.771815	278	1	279
60.0	1.771815	271	0	271
61.0	1.771815	276	0	251
62.0	1.771815	273	0	292
63.0	1.771815	256	2	239
64.0	1.771815	241	0	233
65.0	1.771815	215	1	222
66.0	1.771815	215	0	246
67.0	1.771815	228	1	221
68.0	1.771815	224	1	202
69.0	1.771815	217	1	222
70.0	1.771815	220	1	217
71.0	1.771815	208	0	206
72.0	1.771815	187	0	201
73.0	1.771815	198	1	181
74.0	1.771815	153	1	169
75.0	1.771815	202	1	184
76.0	1.771815	173	0	160
77.0	1.771815	162	0	164
78.0	1.771815	151	0	157
79.0	1.771815	176	0	175
80.0	1.771815	158	2	150
81.0	1.771815	156	0	160
82.0	1.771815	162	0	154
83.0	1.771815	143	0	157
84.0	1.771815	148	0	132
85.0	1.771815	140	0	147
86.0	1.771815	140	0	129
87.0	1.771815	132	0	116
88.0	1.771815	119	0	137
89.0	1.771815	137	0	124
90.0	1.771815	101	1	119
91.0	1.771815	121	0	126
92.0	1.771815	110	0	105
93.0	1.771815	132	0	106
94.0	1.771815	105	0	120
95.0	1.771815	107	0	107
96.0	1.771815	109	0	111
97.0	1.771815	107	0	105
98.0	1.771815	102	0	98
99.0	1.771815	107	0	106
100.0	1.771815	106	0	112
101.0	0	92	0	103
102.0	0	100	0	98
103.0	0	109	0	106
104.0	0	104	0	91
105.0	0	96	0	101
106.0	0	96	0	92
107.0	0	106	0	102
108.0	0	91	0	92
109.0	0	98	0	105
110.0	0	100	0	100
111.0	0	88	0	92
112.0	0	89	0	64
113.0	0	73	0	79
114.0	0	81	0	74
115.0	0	69	0	72
116.0	0	65	0	69
117.0	0	83	0	91
118.0	0	76	0	59
119.0	0	73	0	76
120.0	0	67	0	73
121.0	0	81	0	91
122.0	0	68	0	69
123.0	0	100	0	98
124.0	0	72	0	73
125.0	0	80	0	67
126.0	0	60	0	60
127.0	0	71	0	65
128.0	0	66	0	72
129.0	0	53	0	46
130.0	0	57	0	67
131.0	0	64	0	64
132.0	0	72	0	72
133.0	0	54	0	55
134.0	0	76	0	59
135.0	0	50	0	60
136.0	0	54	0	51
137.0	0	68	0	64
138.0	0	54	0	59
139.0	0	56	0	60
140.0	0	62	0	53
141.0	0	49	0	58
142.0	0	63	0	64
143.0	0	60	1	53
144.0	0	52	0	43
145.0	0	54	0	51
146.0	0	55	0	69
147.0	0	55	0	49
148.0	0	51	0	48
149.0	0	49	0	54
150.0	0	58	0	46
151.0	0	53	0	64
152.0	0	46	0	66
153.0	0	65	0	60
154.0	0	61	0	54
155.0	0	42	0	49
156.0	0	60	0	46
157.0	0	54	0	54
158.0	0	53	0	57
159.0	0	57	0	48
160.0	0	47	0	45
161.0	0	47	0	44
162.0	0	36	0	53
163.0	0	60	0	45
164.0	0	46	0	47
165.0	0	43	0	43
166.0	0	51	0	41
167.0	0	36	0	54
168.0	0	57	0	46
169.0	0	42	0	31
170.0	0	39	0	47
171.0	0	39	0	34
172.0	0	35	0	43
173.0	0	35	0	36
174.0	0	31	0	43
175.0	0	40	0	45
176.0	0	58	0	24
177.0	0	29	0	32
178.0	0	31	0	31
179.0	0	44	0	42
180.0	0	33	0	36
181.0	0	30	0	29
182.0	0	30	0	34
183.0	0	28	0	32
184.0	0	39	0	46
185.0	0	33	0	28
186.0	0	35	0	48
187.0	0	33	0	25
188.0	0	33	0	36
189.0	0	34	0	36
190.0	0	43	0	38
191.0	0	33	0	38
192.0	0	42	0	33
193.0	0	34	0	32
194.0	0	33	0	34
195.0	0	33	0	33
196.0	0	37	0	33
197.0	0	36	0	23
198.0	0	21	0	31
199.0	0	27	0	36
200.0	0	27	0	30
201.0	0	29	0	31
202.0	0	38	0	26
203.0	0	36	0	27
204.0	0	33	0	31
205.0	0	26	0	13
206.0	0	19	0	26
207.0	0	23	0	27
208.0	0	24	0	26
209.0	0	33	0	26
210.0	0	24	0	22
211.0	0	15	0	31
212.0	0	24	0	28
213.0	0	26	0	28
214.0	0	28	0	37
215.0	0	25	0	31
216.0	0	36	0	24
217.0	0	36	0	25
218.0	0	36	0	28
219.0	0	21	0	25
220.0	0	17	0	24
221.0	0	31	0	25
222.0	0	21	0	24
223.0	0	19	0	24
224.0	0	25	0	30
225.0	0	26	0	20
226.0	0	23	0	30
227.0	0	22	0	22
228.0	0	30	0	27
229.0	0	22	0	27
230.0	0	23	0	28
231.0	0	29	0	24
232.0	0	28	0	12
233.0	0	21	0	22
234.0	0	24	0	27
235.0	0	21	0	22
236.0	0	24	0	24
237.0	0	28	0	24
238.0	0	17	0	18
239.0	0	28	0	25
240.0	0	25	0	24
241.0	0	15	0	26
242.0	0	21	0	28
243.0	0	27	0	11
244.0	0	18	0	25
245.0	0	26	0	19
246.0	0	17	0	35
247.0	0	29	0	19
248.0	0	27	0	21
249.0	0	20	0	15
250.0	0	27	0	18
251.0	0	12	0	22
252.0	0	22	0	16
253.0	0	14	0	21
254.0	0	19	0	14
255.0	0	15	0	19
256.0	0	20	0	19
257.0	0	20	0	31
258.0	0	19	0	17
259.0	0	19	0	17
260.0	0	24	0	21
261.0	0	21	0	20
262.0	0	15	0	18
263.0	0	22	0	22
264.0	0	20	0	14
265.0	0	20	0	21
266.0	0	15	0	17
267.0	0	22	0	16
268.0	0	17	0	13
269.0	0	16	0	27
270.0	0	17	0	29
271.0	0	20	0	15
272.0	0	17	0	25
273.0	0	28	0	21
274.0	0	22	0	18
275.0	0	24	0	17
276.0	0	13	0	12
277.0	0	14	0	16
278.0	0	23	0	22
279.0	0	17	0	15
280.0	0	19	0	18
281.0	0	24	0	14
282.0	0	21	0	19
283.0	0	9	0	12
284.0	0	16	0	14
285.0	0	11	0	20
286.0	0	9	0	14
287.0	0	19	0	17
288.0	0	13	0	20
289.0	0	16	0	16
290.0	0	22	0	14
291.0	0	17	0	17
292.0	0	13	0	14
293.0	0	18	0	26
294.0	0	21	0	22
295.0	0	17	0	14
296.0	0	20	0	13
297.0	0	18	0	12
298.0	0	15	0	12
299.0	0	18	0	19
300.0	0	18	0	15
301.0	0	12	0	18
302.0	0	12	0	18
303.0	0	16	0	19
304.0	0	16	0	15
305.0	0	17	0	11
306.0	0	17	0	18
307.0	0	16	0	12
308.0	0	14	0	14
309.0	0	16	0	13
310.0	0	10	0	24
311.0	0	15	0	12
312.0	0	18	0	14
313.0	0	15	0	11
314.0	0	13	0	7
315.0	0	15	0	14
316.0	0	11	0	12
317.0	0	11	0	16
318.0	0	9	0	8
319.0	0	14	0	11
320.0	0	13	0	11
321.0	0	12	0	8
322.0	0	8	0	14
323.0	0	12	0	17
324.0	0	15	0	9
325.0	0	9	0	12
326.0	0	14	0	17
327.0	0	12	0	12
328.0	0	14	0	9
329.0	0	9	0	11
330.0	0	7	0	7
331.0	0	13	0	17
332.0	0	13	0	7
333.0	0	13	0	10
334.0	0	12	0	12
335.0	0	6	0	7
336.0	0	12	0	9
337.0	0	15	0	19
338.0	0	10	0	14
339.0	0	6	0	11
340.0	0	9	0	14
341.0	0	14	0	8
342.0	0	10	0	9
343.0	0	12	0	4
344.0	0	11	0	9
345.0	0	6	0	9
346.0	0	12	0	10
347.0	0	9	0	13
348.0	0	7	0	14
349.0	0	8	0	13
350.0	0	3	0	13
351.0	0	16	0	11
352.0	0	12	0	13
353.0	0	20	0	11
354.0	0	13	0	12
355.0	0	7	0	8
356.0	0	16	0	8
357.0	0	12	0	12
358.0	0	8	0	7
359.0	0	8	0	12
360.0	0	9	0	12
361.0	0	7	0	9
362.0	0	14	0	6
363.0	0	13	0	12
364.0	0	7	0	13
365.0	0	12	0	11
366.0	0	10	0	15
367.0	0	13	0	10
368.0	0	11	0	6
369.0	0	11	0	7
370.0	0	11	0	14
371.0	0	6	0	9
372.0	0	13	0	9
373.0	0	7	0	10
374.0	0	10	0	8
375.0	0	5	0	11
376.0	0	15	0	7
377.0	0	15	0	11
378.0	0	10	0	10
379.0	0	11	0	10
380.0	0	7	0	10
381.0	0	9	0	10
382.0	0	11	0	7
383.0	0	9	0	9
384.0	0	4	0	11
385.0	0	15	0	8
386.0	0	8	0	14
387.0	0	9	0	9
388.0	0	13	0	10
389.0	0	10	0	6
390.0	0	7	0	5
391.0	0	9	0	4
392.0	0	8	0	8
393.0	0	4	0	9
394.0	0	3	0	9
395.0	0	11	0	10
396.0	0	4	0	7
397.0	0	11	0	5
398.0	0	10	0	9
399.0	0	5	0	13
400.0	0	6	0	9
401.0	0	12	0	10
402.0	0	10	0	18
403.0	0	5	0	15
404.0	0	11	0	4
405.0	0	7	0	14
406.0	0	17	0	8
407.0	0	13	0	8
408.0	0	14	0	9
409.0	0	8	0	7
410.0	0	12	0	6
411.0	0	9	0	8
412.0	0	6	0	8
413.0	0	8	0	6
414.0	0	9	0	13
415.0	0	8	0	6
416.0	0	8	0	6
417.0	0	7	0	7
418.0	0	9	0	6
419.0	0	8	0	13
420.0	0	7	0	4
421.0	0	4	0	6
422.0	0	5	0	7
423.0	0	7	0	6
424.0	0	8	0	8
425.0	0	0	0	12
426.0	0	10	0	2
427.0	0	7	0	6
428.0	0	8	0	12
429.0	0	5	0	8
430.0	0	12	0	3
431.0	0	6	0	5
432.0	0	7	0	2
433.0	0	9	0	6
434.0	0	5	0	6
435.0	0	4	0	9
436.0	0	5	0	6
437.0	0	3	0	11
438.0	0	11	0	7
439.0	0	4	0	6
440.0	0	9	0	10
441.0	0	12	0	8
442.0	0	4	0	10
443.0	0	11	0	9
444.0	0	6	0	9
445.0	0	6	0	6
446.0	0	9	0	8
447.0	0	11	0	5
448.0	0	6	0	7
449.0	0	7	0	9
450.0	0	5	0	7
451.0	0	9	0	11
452.0	0	4	0	6
453.0	0	7	0	4
454.0	0	8	0	2
455.0	0	11	0	7
456.0	0	5	0	9
457.0	0	6	0	7
458.0	0	2	0	6
459.0	0	9	0	10
460.0	0	6	0	8
461.0	0	9	0	7
462.0	0	8	0	6
463.0	0	9	0	4
464.0	0	5	0	5
465.0	0	8	0	11
466.0	0	5	0	9
467.0	0	8	0	7
468.0	0	5	0	5
469.0	0	9	0	4
470.0	0	5	0	9
471.0	0	6	0	3
472.0	0	10	0	3
473.0	0	6	0	9
474.0	0	7	0	3
475.0	0	6	0	11
476.0	0	8	0	10
477.0	0	5	0	7
478.0	0	5	0	8
479.0	0	5	0	9
480.0	0	7	0	11
481.0	0	9	0	9
482.0	0	7	0	7
483.0	0	9	0	9
484.0	0	7	0	6
485.0	0	11	0	8
486.0	0	7	0	5
487.0	0	4	0	1
488.0	0	11	0	7
489.0	0	5	0	8
490.0	0	9	0	6
491.0	0	5	0	7
492.0	0	10	0	6
493.0	0	4	0	7
494.0	0	9	0	2
495.0	0	6	0	8
496.0	0	2	0	5
497.0	0	3	0	7
498.0	0	6	0	6
499.0	0	8	0	7
500.0	0	6	0	10
501.0	0	12	0	3
502.0	0	5	0	8
503.0	0	5	0	7
504.0	0	7	0	4
505.0	0	3	0	3
506.0	0	9	0	3
507.0	0	7	0	6
508.0	0	6	0	6
509.0	0	5	0	2
510.0	0	4	0	5
511.0	0	6	0	4
512.0	0	6	0	1
513.0	0	4	0	8
514.0	0	2	0	2
515.0	0	5	0	6
516.0	0	1	0	5
517.0	0	2	0	2
518.0	0	7	0	2
519.0	0	5	0	6
520.0	0	3	0	13
521.0	0	4	0	10
522.0	0	6	0	6
523.0	0	2	0	5
524.0	0	9	0	3
525.0	0	8	0	2
526.0	0	4	0	9
527.0	0	5	0	10
528.0	0	6	0	2
529.0	0	6	0	5
530.0	0	5	0	5
531.0	0	7	0	0
532.0	0	4	0	1
533.0	0	9	0	3
534.0	0	1	0	6
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